For each item, select the ONE best lettered option that is most closely associated with it. Each lettered heading may be selected once, more than once, or not at all. A 45-year-old woman has noticed changes in the fat distribution on her body with excess fat over the posterior neck and upper back. On examination, she has high BP and abdominal striae. Laboratory evaluation shows a high glucose intolerance.
- Cushing's syndrome
- Addison's disease
- Klinefelter syndrome
- hyperparathyroidism
- hypothyroidism
- pheochromocytoma
- acromegaly
- diabetes insipidus
- diabetes mellitus
- polycystic ovarian disease
Answer(s): A
Explanation:
Cushing's syndrome is caused by overproduction of cortisol by the adrenal gland. Centripetal obesity occurs in 97% of patients, increased body weight in 94%, fatigability and weakness in 87%, and hypertension in 82%. Impaired glucose tolerance is common and attributable to increased hepatic gluconeogenesis and insulin resistance.