Cisco
CompTIA
ISC
EC-Council
EXIN
Fortinet
ITIL
Juniper
Microsoft
VMware
Avaya
SAP
Google
NVIDIA
Salesforce
Amazon
Palo Alto Networks
ISC2
Splunk
ServiceNow
All Vendors
  2. Home
  3. Exams
  4. MRCPUK
  5. SEND

MRCPUK SEND Exam
SEND - Endocrinology and Diabetes (Specialty Certificate Examination) (Page 6 )

Updated On: 12-Jan-2026
Page 6 of 51
PDF with 200 Questions

A 24-year-old woman was referred with an 18-month history of worsening hirsutism, primarily on her face, but also new hair growth on her chest. She was shaving weekly. She had always been overweight, but had recently gained 5 kg and her body mass index was 31 kg/m2 (18–25). Her periods were regular.
What is the most relevant next investigation?

  1. overnight dexamethasone suppression test (after 1 mg dexamethasone)
  2. plasma thyroid-stimulating hormone
  3. serum 17-hydroxyprogesterone
  4. serum dehydroepiandrosterone
  5. serum testosterone

Answer(s): E



A 77-year-old woman presented with a 10-week history of facial hirsutism, scalp hair loss and deepening of the voice.
On examination, her body mass index was 32 kg/m2 (18–25). Her blood pressure was 164/94 mmHg. She had coarse terminal hairs on her upper lip and beard areas. Abdominal examination was normal, but she refused examination of her external genitalia.
Investigations:

-serum sodium144 mmol/L (137–144) serum potassium3.6 mmol/L (3.5–4.9) serum urea7.7 mmol/L (2.5–7.0) serum creatinine122 µmol/L (60–110)
-fasting plasma glucose6.4 mmol/L (3.0–6.0) serum testosterone17.2 nmol/L (0.5–3.0) serum luteinising hormone2.2 U/L (>30.0)

What is the most appropriate initial investigation?

  1. CT scan of abdomen and pelvis
  2. overnight dexamethasone suppression test (after 1 mg dexamethasone)
  3. plasma adrenocorticotropic hormone and serum cortisol
  4. serum dehydroepiandrosterone sulphate
  5. serum oestradiol

Answer(s): A



A 27-year-old woman with type 1 diabetes mellitus was invited to attend a structured education (e.g. DAFNE) course. Which quality of life domain is most affected when a person is found to have type 1 diabetes mellitus?

  1. enjoyment of leisure activities
  2. family life
  3. freedom to eat as one wishes
  4. sex life
  5. working life and work-related opportunities

Answer(s): C



A 44-year-old man was referred for investigation of cortisol excess. He had poorly controlled hypertension, and a long history of type 2 diabetes mellitus with retinopathy and peripheral neuropathy. His medication comprised aspirin, ramipril, atenolol, carbamazepine, metformin and simvastatin.

Initial investigations:

-serum cortisol (09.00 h)350 nmol/L (200–700)
-serum cortisol (22.00 h)48 nmol/L (50–250)
-overnight dexamethasone suppression test (after 1 mg dexamethasone): serum cortisol93 nmol/L (<50)
-24-h urinary free cortisol (day 1)225 nmol (55–250) 24-h urinary free cortisol (day 2)200 nmol (55–250)
-24-h urinary free cortisol (day 3)185 nmol (55–250)

What is the most appropriate next step in management?

  1. CT scan of adrenal glands
  2. dexamethasone-suppressed corticotrophin-releasing hormone test
  3. high-dose 48-h dexamethasone suppression test
  4. MR scan of pituitary
  5. reassure and discharge

Answer(s): E



Viewing page 6 of 51
Viewing questions 21 - 24 out of 200 questions



Post your Comments and Discuss MRCPUK SEND exam prep with other Community members:

Join the SEND Discussion