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USMLE STEP2 Exam
Step2 (Page 22 )

Updated On: 30-Jan-2026
Page 22 of 149
PDF with 738 Questions

From the below the clinical indications, choose an option for use of immune globulin (IG) in Hepatitis B prophylaxis

  1. indicated
  2. not proven effective
  3. not routinely indicated
  4. contraindicated
  5. compulsory

Answer(s): B

Explanation:

IG given before exposure or within 14 days of exposure is 7585% effective in preventing symptomatic illness from hepatitis A. IG is produced from the plasma of normal adults and does not contain sufficient antibody to prevent hepatitis B infection. Hepatitis B immune globulin (HBIG) is prepared from plasma known to contain high antibody titers for hepatitis B surface antigen (HBsAg) and is specific for hepatitis B.
Given immediately postexposure, and again 1 month later, it has a combined efficacy of about 75% in the prevention of hepatitis B. Postexposure IG has not been found effective in the prevention of hepatitis C infection; on the other hand, treatment of early hepatitis C infection is possible, and thus it is important to monitor exposed individuals to determine whether infection occurs. IG administered to individuals exposed to measles infection who are susceptible to the disease has been shown to be effective if given within 6 days of exposure.
Recent use of IG is a contraindication to immunization with rubella vaccine. IG is not very effective at preventing in utero infection with rubella, and infants with congenital rubella syndrome have been born to women given IG shortly after exposure. IG is not routinely indicated, as it is indicated only if abortion is not elected.



From the below the clinical indications, choose an option for use of immune globulin (IG) in Hepatitis C prophylaxis

  1. indicated
  2. not proven effective
  3. not routinely indicated
  4. contraindicated
  5. compulsory

Answer(s): B

Explanation:

IG given before exposure or within 14 days of exposure is 7585% effective in preventing symptomatic illness from hepatitis A. IG is produced from the plasma of normal adults and does not contain sufficient antibody to prevent hepatitis B infection. Hepatitis B immune globulin (HBIG) is prepared from plasma known to contain high antibody titers for hepatitis B surface antigen (HBsAg) and is specific for hepatitis B.
Given immediately postexposure, and again 1 month later, it has a combined efficacy of about 75% in the prevention of hepatitis B. Postexposure IG has not been found effective in the prevention of hepatitis C infection; on the other hand, treatment of early hepatitis C infection is possible, and thus it is important to monitor exposed individuals to determine whether infection occurs. IG administered to individuals exposed to measles infection who are susceptible to the disease has been shown to be effective if given within 6 days of exposure.
Recent use of IG is a contraindication to immunization with rubella vaccine. IG is not very effective at preventing in utero infection with rubella, and infants with congenital rubella syndrome have been born to women given IG shortly after exposure. IG is not routinely indicated, as it is indicated only if abortion is not elected.



From the below the clinical indications, choose an option for use of immune globulin (IG) in Measles prophylaxis

  1. indicated
  2. not proven effective
  3. not routinely indicated
  4. contraindicated
  5. compulsory

Answer(s): A

Explanation:

IG given before exposure or within 14 days of exposure is 7585% effective in preventing symptomatic illness from hepatitis A. IG is produced from the plasma of normal adults and does not contain sufficient antibody to prevent hepatitis B infection. Hepatitis B immune globulin (HBIG) is prepared from plasma known to contain high antibody titers for hepatitis B surface antigen (HBsAg) and is specific for hepatitis B.
Given immediately postexposure, and again 1 month later, it has a combined efficacy of about 75% in the prevention of hepatitis B. Postexposure IG has not been found effective in the prevention of hepatitis C infection; on the other hand, treatment of early hepatitis C infection is possible, and thus it is important to monitor exposed individuals to determine whether infection occurs. IG administered to individuals exposed to measles infection who are susceptible to the disease has been shown to be effective if given within 6 days of exposure.
Recent use of IG is a contraindication to immunization with rubella vaccine. IG is not very effective at preventing in utero infection with rubella, and infants with congenital rubella syndrome have been born to women given IG shortly after exposure. IG is not routinely indicated, as it is indicated only if abortion is not elected.



From the below clinical indications, choose an option for use of immune globulin (IG) in Rubella prophylaxis

  1. indicated
  2. not proven effective
  3. not routinely indicated
  4. contraindicated
  5. compulsory

Answer(s): C

Explanation:

IG given before exposure or within 14 days of exposure is 7585% effective in preventing symptomatic illness from hepatitis A. IG is produced from the plasma of normal adults and does not contain sufficient antibody to prevent hepatitis B infection. Hepatitis B immune globulin (HBIG) is prepared from plasma known to contain high antibody titers for hepatitis B surface antigen (HBsAg) and is specific for hepatitis B.
Given immediately postexposure, and again 1 month later, it has a combined efficacy of about 75% in the prevention of hepatitis B. Postexposure IG has not been found effective in the prevention of hepatitis C infection; on the other hand, treatment of early hepatitis C infection is possible, and thus it is important to monitor exposed individuals to determine whether infection occurs. IG administered to individuals exposed to measles infection who are susceptible to the disease has been shown to be effective if given within 6 days of exposure.
Recent use of IG is a contraindication to immunization with rubella vaccine. IG is not very effective at preventing in utero infection with rubella, and infants with congenital rubella syndrome have been born to women given IG shortly after exposure. IG is not routinely indicated, as it is indicated only if abortion is not elected.



Select the appropriate incubation period of the Diphtheria infectious disease of childhood.

  1. 16 days
  2. 78 days
  3. 810 days
  4. 1021 days
  5. 3050 days
  6. 120180 days

Answer(s): A

Explanation:

The incubation period for diphtheria is 17 days. The incubation period for chicken pox is 1021 days, average 14. Infectious mononucleosis, caused by the Epstein-Barr virus, has an estimated incubation period of 3050 days. The incubation period following infection by the mumps virus is usually 1618 days but, like chicken pox, may vary from 14 to 25 days. Pertussis has a shorter incubation period, usually 710 days, with a variation of 421 days. The usual period from contamination with tetanus spores to clinical symptoms is generally 68 days. For rubella, the incubation period is from 14 to 21 days, but usually ranges from 16 to 18 days.



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