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Which Cytochrome P450 isozyme does not participate appreciably in drug metabolism?

  1. CYP1A2
  2. CYP2C9
  3. CYP3A4
  4. CYP51
  5. All are drug metabolizing isoforms

Answer(s): D



Which of the following Cytochrome P450 isozymes is responsible for the bulk of phase I metabolism?

  1. CYP1A2
  2. CYP2C9
  3. CYP2D6
  4. CYP3A4
  5. CYP51

Answer(s): E



Which of the following enzymes could metabolize ethanol?

  1. Cytochrome P450
  2. Alcohol Dehydrogenase
  3. Glucuronyl Transferase
  4. Sulfotransferase
  5. All of the above

Answer(s): E



Which of the following are similarities between Cytochrome P450 and MAO?

  1. Both add oxygen from O2 to substrates and also form water
  2. Both carry out direct heteroatom oxidations
  3. Both carry out oxidative deaminations
  4. Both carry out N-dealkylations
  5. All of the above

Answer(s): C






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