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In a zero order elimination process, which of the following is true?

  1. The removal of drug is independent of drug concentration
  2. Cl = Elimination rate/Cp
  3. t1/2 = .7VD/Cl
  4. All are true

Answer(s): A



For highly polar drugs (e.g. mannitol) what primarily determines elimination rate?

  1. Excretion rate
  2. Metabolism rate
  3. Absorption rate
  4. Distribution rate
  5. All of the above

Answer(s): A



Bioavailability is related to which of the following parameters, according to the equation
F = 1 - E

  1. Excretion
  2. Elimination
  3. Extraction Ratio
  4. Enterohepatic Recycling

Answer(s): C



For the majority of drugs, which of the following equations correctly defines clearance?

  1. Cl = Elimination rate/Cp
  2. Cl = QxE
  3. Cl = .7VD/t1/2
  4. All are correct

Answer(s): D






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