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NABP FPGEE Exam
Foreign Pharmacy Graduate Equivalency Examination (Page 3 )

Updated On: 9-Feb-2026
Page 3 of 87
PDF with 456 Questions

Given that the VD = 230 L/70Kg and Cl = 60 L/hr/70 Kg for morphine, approximately how much of a 10 mg IV dose remains after 8 hr, given to a normal 70 Kg patient?

  1. 5 mg
  2. 2.5 mg
  3. 1.25 mg
  4. 625 mg

Answer(s): C



Given F = .24, what is the overall hepatic clearance of morphine if the above patient has portal hypertension such that their hepatic blood flow is reduced by ½? Assume the clearance value given in the previous question is entirely hepatic clearance.

  1. 30 L/hr/70 Kg
  2. 60 L/hr/70 Kg
  3. 120 L/hr/70 Kg
  4. 250 L/hr/70 Kg

Answer(s): A



Which of the following enzymes could directly act on codeine?

  1. Glucuronyl transferase
  2. Sulfotransferase
  3. Glutathione transferase
  4. A & B
  5. All of the above

Answer(s): D



Which Cytochrome P450 isozyme does not participate appreciably in drug metabolism?

  1. CYP1A2
  2. CYP2C9
  3. CYP3A4
  4. CYP51
  5. All are drug metabolizing isoforms

Answer(s): D



Which of the following Cytochrome P450 isozymes is responsible for the bulk of phase I metabolism?

  1. CYP1A2
  2. CYP2C9
  3. CYP2D6
  4. CYP3A4
  5. CYP51

Answer(s): E






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