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North American Pharmacist Licensure Examination Questions 41–45 (page: 10)

Updated On: 9-Feb-2026

You need 51.3 mEq of NaCl to make 1/3 NS 1 liter bag. How many ml of 23.4% NaCl would you need? (Molecular weight of Na is 23 and Cl is 35.5)

  1. 12.82ml
  2. 16.82ml
  3. 23.4ml
  4. 58.5ml
  5. 10ml

Answer(s): A

Explanation:

1mEq NaCl= 58.5; Valence = 1. mg = mEq × molecular weight / valence. mg = 51.3mEq × 58.5mg / 1 = 3001.05mg = 3g. 23.4 g/100ml = 3g/Xml X = 12.825mL



Which of the following is/are a risk factor for myopathy with statin therapy?

  1. Hypothyroidism
  2. Vitamin D deficiency
  3. Renal impairment
  4. Hepatic dysfunction
  5. Vitamin C deficiency

Answer(s): D

Explanation:

Risk factors for myopathy are hypothyroidism, reduced renal or hepatic function, rheumatologic disorders such as polymyalgia rheumatica, steroid myopathy, vitamin D deficiency, or primary muscle diseases.



Which of the following is considered first-line therapy for reducing the risk of atherosclerotic cardiovascular disease (ASCVD)?

  1. HMG Co-A reductase inhibitors
  2. Bile acid resins
  3. Nicotinic Acid
  4. Fibrates
  5. Fish oil

Answer(s): A

Explanation:

ATP4 found that the use of statins for prevention of ASCVD is extensive and consistent. Statin therapy is recommended for patients at a higher risk of ASCVD who are most likely to experience a net benefit in terms of the potential for risk reduction vs the potential for adverse effects. Non-statin therapies do not provide sufficient benefits in the reduction of ASCVD risk in regards to their potential for adverse effects.



If you mix 30 gm 5% lidocaine cream and 90gm of 0.5% hydrocortisone cream, what percent of lidocaine and hydrocortisone do you have as the end product?

  1. Lidocaine/Hydrocortisone 2%/1.25%
  2. Lidocaine/Hydrocortisone 0.375%/0.15%
  3. Lidocaine/Hydrocortisone 1.25 %/ 0.15%
  4. Lidocaine/Hydrocortisone 2% /0.25%
  5. Lidocaine/Hydrocortisone 1.25% /0.375%

Answer(s): E

Explanation:

Lidocaine: 30g × 0.05 = 1.5g. Hydrocortisone: 90g × 0.005 = 0.45g. 90g + 30g = 120g. 1.5g/120g = 0.0125 × 100 = 1.25% Lidocaine. 0.45g/120g = 0.00375 × 100 = 0.375% Hydrocortisone.



In a study where Rivaroxaban was compared to enoxaparin to find total VTE following HIP replacement surgery, there were 17 total VTE out of 1513 patients in the Rivaraoaban group and 57 total VTE out of 1473 patient in the enoxaparin group. What is the relative risk reduction of using Rivaroxaban over Enoxaparin?

  1. 39%
  2. 71%
  3. 29%
  4. 14%
  5. 42%

Answer(s): B

Explanation:

Relative risk reduction: 0.71 = 71% Relative risk: (Event rate in rivaroxaban group)/(Event rate in enoxaparin group) = (17/1513)/(57/1473) = 0.2903 Relative risk reduction: 1 – (relative risk) = 1 – 0.2903 = 0.7097 = 0.71.



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