QUESTION: 45

In a study where Rivaroxaban was compared to enoxaparin to find total VTE following HIP replacement surgery, there were 17 total VTE out of 1513 patients in the Rivaraoaban group and 57 total VTE out of 1473 patient in the enoxaparin group. What is the relative risk reduction of using Rivaroxaban over Enoxaparin?

Answer(s): B

Explanation:

Relative risk reduction: 0.71 = 71% Relative risk: (Event rate in rivaroxaban group)/(Event rate in enoxaparin group) = (17/1513)/(57/1473) = 0.2903 Relative risk reduction: 1 – (relative risk) = 1 – 0.2903 = 0.7097 = 0.71.

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QUESTION: 46

An order is received for heparin 18 units per kg per hour on a patient whose weight is 125lb. The IV bag comes as a concentration of 50 units /mL. Calculate the infusion rate in terms of mL/hr.

5.15 mls/hr
10.23 mls/hr
40.9 mls/hr
20.45 mls/hr
18 mls/hr

Answer(s): D

Explanation:

125 lb =56Kg, 56Kg × [18 units/ 1 kg] = 1022.72 units/hr, 1022.72 units × [1 mL/50 units] = 20.45 mL/hr

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QUESTION: 47

According to the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to ReduceAtherosclerotic Cardiovascular Risk in Adults, which of the following LDL cholesterol thresholds is an indication for high- intensity statin therapy?

≥ 100 mg/dL
≥ 130 mg/dL
≥ 190 mg/dL
≥ 200 mg/dL
≥ 150 mg/dL

Answer(s): C

Explanation:

Statin therapy should be used as treatment in adults with primary LDL–C ≥190 mg/dL and age over 21 years. Unless contraindicated, high-intensity statin therapy should be used.

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QUESTION: 48

Injectable Sulfamethoxazole/Trimethoprim comes as 400mg/80mg/5ml. Physician requests you to dose a Sulfamethoxazole/Trimethoprim intravenously for PCP. You know the dose is 15mg/kg/day (based on TMP component) divided q6h.
How many milliliters of Sulfamethoxazole/Trimethoprim of 400mg/80mg/5ml would you need for single dose? Patient weighs 80kg.

18.75 mL
75 mL
15 mL
50 mL
16.5 mL

Answer(s): A

Explanation:

80kg person = 15mg/kg/day = 1200mg/day 80mg /5ml = 1200mg/X X= 75mL/day / 4 doses = 18.75 mL per dose

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